Beauty Application to Cosmetics
Supply of cosmetic raw materials
Cysay Factor® is a supernatant solution of immortalized human dental pulp stem cell acclimatized culture = Cysay Factor® is supplied as a cosmetic raw material in 100% undiluted form.
*Cysay factor® is a culture supernatant obtained from immortalized stem cells (currently manufactured from immortalized dental pulp stem cells).
The main feature of Cysay factor®, produced from stem cells immortalized by our patented immortalization technology, is that the bioactive substances such as cytokines, exosomes, and chemokines are always uniform during production.
This quality control, which was considered difficult to achieve with culture supernatants, is made possible by Cysay's patented immortalization technology, which is unique to Cysay.
*Patent 6010112 (PCT/JP203/059376)
*Patent No. 6868565 (PCT/JP2016/082975)
Cysay Factor® is safe and secure because it is a culture supernatant made from traceable donor stem cells.
Traceability means that it is possible to identify when, where, and by whom the product was made.
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Cysay
Immortalized Human Dental Pulp Stem Cell Acculturation Solution = Cysay Factor ®︎ Features
- The use of ImS cells (immortalized stem cells) makes it possible to control the quality of culture supernatant.
- Many in vtro experiments have been performed.
- 100% culture supernatant stock solution, no dilution at all
- Each lot undergoes safety and quality inspections, including a virus stability test in accordance with the Japanese Pharmacopoeia.
- Patented technology for immortalizing stem cells and culturing them in Japan and abroad
We supply safe and reliable raw materials to our customers.
in vitro experimental results
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Whitening effect
When Cysay Factor® ®︎, another company's culture supernatant, and arbutin were added to dark cells (n/c) and their whitening effects were compared, Cysay Factor® ®︎ reduced melanin and made the cells whiter (Figure 1).
<Figure 1> Whitening action of Cysay Factor
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Moisturizing action
Cysay factor ®︎ produces aquaporins, which increase water content at the cellular level
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Experiments on collagen production, collagenolytic enzyme inhibition, and aquaporin production using aged fibroblast cells
Cysay Factor® was found to have potency against aged fibroblasts.In aging cells, it is not only the collagen production that is important, but also the inhibition of collagenolytic enzymes that is important.
Experimental results show that Cysay Factor® produces collagen and inhibits its further degradation.
Also, only Cysay factor ®︎ produced aquaporins in senescent cells.
